Neuroligin



Neuroligins (NLGN) are a family of postsynaptic proteins which bind to the presynaptic Neurexin (NRXN) to form a complex which attaches neurons. The NLGN family contains 4 members which are numbered 1 to 4. The images at the left and at the right correspond to one representative NLGN, i.e. the crystal structure of human Neuroligin (3be8).

For Structural Analysis of Neuroligin, See: Neuroligin-Neurexin Interaction

NLGN
3bl8 - mNLGN-2 cholinesterase domain – mouse

3be8 - hNLGN-4 cholinesterase domain – human

3bix - rNLGN-1 cholinesterase domain - rat

NLGN+NRXN
2xb6, 2wqz – hNLGN-4 cholinesterase domain+NRXN-1β LNS domain

3b3q - mNLGN-4 cholinesterase domain+NRXN-1β LNS domain

3biw - rNLGN-1 cholinesterase domain+NRXN-1β LNS domain